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LNA™ Monomers Nucleic Acid Duplex Melting Temperature (Tm)

Incorporation of LNA™ monomers in one strand of a nucleic acid duplex will increase the melting temperature (Tm) of the duplex with 2-8°C per LNA™ monomer. Thus, LNA™ vastly improves the thermal stability and specificity of duplexes formed with complementary DNA or RNA.

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