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what is bridged nucleic acids - BNA

Bridged nucleic acid 2',4'-BNANC (2'-O,4'-aminoethylene bridged nucleic acid) RNA analogue, containing a six-member bridged structure with an N-O linkage, was developed by Professor Emeritus Takeshi Imanishi of Osaka University. These novel nucleic acid analogues can be synthesized and incorporated into oligonucleotide. When compare to the earlier generation of 2', 4' BNA (LNA)- modified oligonucleotides, 2', 4'-BNANC [N-Me] analogues were found to possess:
  • Higher binding affinity against an RNA complement with excellent single-mismatch discriminating power,
  • Enhanced RNA selective binding,
  • Stronger and more sequence selective triplex-forming characters, and
  • Stronger nuclease resistance to endo and exo-nucleases, even higher than the S(p)-phosphorothioate analogue.

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