End Blocker Oligo Modification
Bio-Synthesis end blocker modification can be incorporate at 5' or 3' end of an oligonucleotide using 5'-5'' or 3'-5' synthesis strategy.
Every oligo synthesized is strictly controlled for quality by using either MALDI-TOF mass spectrometry or polyacrylamide gel electrophoresis (PAGE) analysis. Final yields are determined using UV absorbance at OD260 In addition, we perform QC methods tailored to specific modifications, such as OD ratio measurement where appropriate.
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