The ability to create functional biomolecules through bioconjugation has affected every conceivable discipline in the life sciences. The application of available cross-linking reactions and reagent systems for creating novel conjugates with peculiar activities has made it possible for applications such as ligand discovery, disease diagnosis, and high-throughput screening. These powerful methods owe their existence to the discovery of chemoselective reactions that enable bioconjugation under physiological conditions, a tremendous advancement for next generation drug development.
Bio-Synthesis, a leading biology CRO, focuses exclusively on early drug discovery and development services. Relying on our state-of-the-art manufacturing facility and over 30 years of combined experience in complex API conjugate techniques, our bioconjugation-based drug discovery and development program have delivered thousands of hybrid complexes. Our in-house bioanalytical laboratory offers a full spectrum of analytical tools capable of producing technically challenging, yet safe and efficacious drug conjugates. From project scope analysis and problem solving proposals to complex biopolymer production and assay development, we strive with competence and confidence to meet your demand for creating novel conjugates that can be quickly and cost-effectively added to your value chain. Bio-Synthesis, your partner in therapeutic drug innovation.
We offer personalized solution for the conjugation of small molecules such as drugs, metabolites, and labeled compounds with synthetic or natural polymers for specific applications. Our conjugation services include:
At Bio-Synthesis, custom bioconjugation reagents are manufactured under a strict quality control process to assure customers' complete satisfaction. Our sizeable investment in state-of-the-art analytical equipment provides industry-leading tools to develop and monitor our process. Complementary techniques, such as analytical chromatography and electrophoresis, are routinely used to verify that specifications are met. Sometimes, if the biopolymer is not too massive, mass spectroscopy can be used to determine its molecular weight. However, unless a crystal structure is available or a single unique functional group was used for conjugation, it may be difficult to know the exact conjugation site and the molar ratio of the reactants. Because of this complexity and difficulty, the effort required assessing the composition and purity of a bioconjugate depends largely on the requirements and rigor of the downstream research. At Bio-Synthesis, we strive with competence and confidence to meet your demand for developing pre-clinical drug candidates or innovative regents and tools efficiently and affordably. With our track record, Bio-Synthesis is your ideal and reliable innovation partner in targeted drug discovery.
The application of available chemical reactions and reagent system through bioconjugation chemistry for creating novel complexes with unique activities and have been used in the area of: