Standard & Modified PNA Synthesis

Custom peptide nucleic acid (PNA) oligomers—from conventional A/C/G/T sequences to fluorescent probes, backbone-modified PNAs and complex conjugates. Bio-Synthesis supports synthesis planning, preparative HPLC purification, and analytical quality control for research and development.

Standard PNA Modified PNA HPLC purification MS identity QC Research & custom bulk

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Overview Synthesis Services Synthesis Scale Modifications Purification & QC Applications Related Services Reading FAQ Contact

Peptide nucleic acid platform · Flexible scale · Custom chemistry

Custom PNA Synthesis. From Discovery to Scale.

Peptide nucleic acid (PNA) is a synthetic nucleic-acid analog built on a neutral N-(2-aminoethyl)glycine backbone instead of the natural sugar–phosphate backbone. Its nucleobases recognize complementary DNA and RNA through sequence-specific pairing, making PNA a versatile tool for molecular imaging, PCR clamping, mutation analysis, affinity capture, and nucleic-acid research.

Bio-Synthesis supports standard and modified PNA synthesis across a flexible range of proposed scales—from early feasibility studies and small research orders to multi-micromole synthesis and larger custom quantity requests. Choose conventional A/C/G/T PNA or explore tailored chemistry such as fluorescent dyes, biotin and affinity labels, γ-backbone modifications, nucleobase analogs, PEG/AEEA linkers, reactive handles, and peptide–PNA conjugates. Each project can be planned around its sequence, modification complexity, purified quantity, and analytical requirements.

SCALE FLEXIBILITY

Start small. Scale with your research.

View proposed synthesis scales →

01 / DISCOVERY

25–100 nmol

Initial evaluation & probe screening

02 / RESEARCH

250–500 nmol

Assay development & repeat studies

03 / EXPANDED

1–10 nmol

Higher-volume research needs

04 / CUSTOM

Bulk requests

Project-specific scale & yield review

Illustrative, proposed synthesis scales—not guaranteed purified yields or confirmed standard production limits. Availability depends on sequence and chemistry.

Standard PNA

Sequence-defined PNA oligomers with terminal chemistry and HPLC purification options.

Multiple Modification Types

Backbone and base engineering, dyes, affinity tags, spacers, reactive handles, and conjugates.

Explore modification options →

Purified & Characterized

Preparative HPLC, analytical purity assessment, and molecular mass confirmation tailored to the project.

From sequence to purified PNA

Specify your sequence, modification sites, desired scale or final purified amount, purity target, and application. Our technical team reviews feasibility and QC before quotation.

Discuss your project →

Choose your synthesis service

Two PNA Synthesis Options

Start with the chemistry your application requires. Both service pathways can include preparative HPLC purification and analytical HPLC / mass spectrometry QC.

SERVICE 01 · STANDARD

Standard PNA Synthesis

Sequence-defined PNA oligomers with conventional A, C, G and T nucleobases on the neutral PNA backbone. Suitable for routine hybridization, PNA clamps and research probes.

Custom A/C/G/T PNA sequences
Selected N-terminal and C-terminal configurations
Optional lysine additions for solubility
Research and larger custom quantities
Preparative HPLC purification with analytical QC

Unlabeled PNA HPLC purified LC-MS / MS

Request Standard PNA Quote →

SERVICE 02 · CUSTOM MODIFIED

Modified PNA Synthesis

Customized PNA incorporating labels, specialized monomers, functional groups or conjugates for advanced imaging, molecular recognition and assay development.

γ-PNA and selected backbone-modified designs
Noncanonical nucleobases and specialized recognition
Fluorescent dyes, quenchers and affinity tags
PEG/AEEA linkers and click-chemistry handles
PNA–peptide and other complex conjugates

Modified bases Fluorescent PNA Conjugates

Request Modified PNA Quote →

Flexible quantities

Proposed PNA Synthesis Scales & Custom Yield Options

Select a research synthesis scale or request a specific final purified amount. The following is a proposed commercial menu; Bio-Synthesis should confirm validated production capabilities before publishing it as a standard offering.

Research & preparative synthesis

Nominal Synthesis Scales

25 nmol 50 nmol 100 nmol 250 nmol 500 nmol 1 µmol 2 µmol 5 µmol 10 µmol

Nominal synthesis scale is not the final recovered or guaranteed purified yield.

Custom production

Purified Milligram & Bulk Orders

1 nmol 5 mg 10 mg 25 mg 50 mg 100 mg 250 mg Gram-scale review

Custom amounts are quoted by final product target, sequence complexity, modification, purity and manufacturing feasibility.

Important scale distinction: Synthesis scale refers to the nominal starting synthesis capacity; delivered quantity refers to purified product after synthesis, cleavage, purification and recovery. Purity and final yield are established in the project quotation.

Modified PNA capabilities

Explore PNA Modification Options

Explore ten PNA modification categories with a detailed, representative library of backbone designs, nucleobases, labels, linkers, reactive groups, conjugates and higher-order architectures. Listed options are not a guarantee of routine availability; specialized monomers and constructs require project-specific feasibility review.

Backbone & structural

Modification	Type	Purpose / considerations
γ-PNA	Gamma-substituted PNA	Preorganized chiral backbone; sequence-specific affinity and solubility evaluation.
miniPEG-γ-PNA	Hydrophilic γ-PNA	MiniPEG side chain for solubility and backbone preorganization.
α-/β-substituted PNA	Backbone variants	Specialized monomer chemistry and feasibility review.
Constrained PNA	Conformationally restricted	Research-oriented backbone engineering; custom feasibility.
Chiral γ-PNA patterns	Position-specific backbone modification	Single or multiple γ-substitutions and stereochemical placement; feasibility review.
Mixed standard/γ-PNA	Hybrid backbone design	Combine conventional and γ-substituted residues for comparative recognition studies.
Cyclic / conformationally constrained PNA	Constrained scaffold	Macrocyclic or restricted architectures; route and binding performance require design review.
Stereodefined backbone designs	Backbone stereochemistry	Chiral monomer placement and stereochemical control require reagent and route confirmation.

Modified nucleobases

Modification	Type	Purpose / considerations
Pseudoisocytosine (J)	Base analog	Used in selected Hoogsteen-recognition and triplex PNA designs.
2,6-Diaminopurine (D)	Adenine analog	Alternative T-recognition and binding studies.
G-clamp analogs	Cytosine analog	Enhanced guanine recognition in selected designs.
5-Methylcytosine	Methylated cytosine analog	Modified nucleobase for selected recognition studies; monomer feasibility review.
Hypoxanthine / inosine-like bases	Purine analog	Alternative base-pairing studies; assess target specificity and monomer availability.
Thiouracil / thio-base analogs	Sulfur-modified base	Specialized base recognition or photochemical research; structure-dependent feasibility.
Halogenated base analogs	Halogenated nucleobase	Specialty recognition or reporter research; custom monomer sourcing.
Universal-base analogs	Base analog	Broad-pairing concepts require experimental validation and custom synthesis review.
Other noncanonical bases	Custom monomers	Structure and monomer availability assessed case by case.

Terminal modifications

Modification	Type	Purpose / considerations
N-acetyl / C-amide	Terminal groups	Defined end-group chemistry and charge.
Free amine / carboxyl	Reactive termini	Conjugation and downstream derivatization.
C-terminal acid / amide / amine	End-group configuration	Match the downstream attachment or assay requirements.
N-terminal amino group	Terminal functionality	Free terminal amine for coupling or charge management.
Terminal thiol / cysteine	Terminal functionality	Thiol coupling or immobilization; oxidation control may be needed.
Terminal biotin	Terminal affinity tag	Streptavidin-mediated detection or capture; linker placement matters.
Terminal azide / alkyne	Terminal click handle	CuAAC or SPAAC-ready designs depending on the complementary partner.
Terminal digoxigenin	Terminal affinity tag	Antibody-based detection in compatible assay formats.

Fluorescent labels

Modification	Type	Purpose / considerations
FAM / FITC / HEX	Fluorescent dyes	Green/yellow fluorescence; FISH and imaging.
TAMRA / ROX / Cy3	Fluorescent dyes	Orange/red detection and multiplex designs.
Cy5 / Cy5.5 / ATTO / Alexa Fluor	Fluorescent dyes	Far-red and specialty imaging; dye compatibility reviewed.
Cy7 / near-IR dyes	Near-infrared labeling	Imaging and optical detection; photophysical and synthetic compatibility reviewed.
Fluorescein derivatives	Fluorescent label	Green-channel labeling; dye and attachment-site compatibility reviewed.
ATTO 488 / ATTO 550 / ATTO 647N	Fluorescent label family	Specific ATTO dye choices depend on excitation/emission and coupling chemistry.
Alexa Fluor 488 / 555 / 647	Fluorescent label family	Selected Alexa Fluor labels subject to reagent availability and conjugation route.
Dual fluorescent labels	Dual labeling	FRET or multiplex configurations; spacing and optical properties require review.

Quenchers & optical

Modification	Type	Purpose / considerations
DABCYL / BHQ	Quenchers	Specialized fluorescence-switching and beacon constructs.
Dual dye / quencher constructs	FRET or beacon formats	Fluorophore–quencher spacing and signal response are design dependent.
BHQ-1 / BHQ-2 / BHQ-3	Dark quenchers	Match quencher absorption to fluorophore emission; verify chemistry.
FRET donor–acceptor pairs	Optical reporter	Donor–acceptor spacing and spectral overlap control signal behavior.
PNA molecular beacons	Optical probes	Dual-labeled detection constructs.
Photocleavable optical linkers	Light-responsive linkage	Photorelease or optical control concepts; wavelength and stability review.

Spacers & linkers

Modification	Type	Purpose / considerations
AEEA / PEG spacers	Hydrophilic linkers	Separate PNA recognition segment from dyes or ligands.
Aminohexanoic acid (Ahx)	Alkyl spacer	Flexible separation of recognition and conjugate.
Lysine (K) tails	Solubility additions	Can improve handling of selected PNA sequences.
PEG4 / PEG12 / custom PEG lengths	Variable-length hydrophilic spacers	Tune separation between recognition domain and cargo.
AEEA repeats / miniPEG	Hydrophilic spacer architecture	Improve distance and handling in selected conjugate designs.
Flexible alkyl linkers	Spacer	Alkyl chain length and hydrophobicity tailored to the application.
Disulfide-cleavable linkers	Redox-responsive spacer	Potential reductive release; evaluate synthesis and assay conditions.
Photocleavable linkers	Stimulus-responsive spacer	Light-triggered cleavage concepts; feasibility and wavelength selection.

Reactive handles

Modification	Type	Purpose / considerations
Thiol / cysteine	Sulfur handle	Thiol-specific coupling and surface attachment.
Azide / alkyne	Click chemistry	CuAAC-compatible conjugation designs.
DBCO	Copper-free click	SPAAC coupling to azide-functionalized partners.
Maleimide / NHS ester	Reactive coupling	Site-specific coupling strategy subject to stability and compatibility.
BCN	Copper-free click handle	Strain-promoted coupling to azide-functionalized partners.
Aminooxy / hydrazide	Carbonyl-selective handles	Oxime or hydrazone ligation concepts for compatible partners.
Activated ester / carboxyl	Amide-forming chemistry	Partner-dependent coupling and protection strategy.
Orthogonally protected coupling handles	Selective conjugation	Site-selective modification requires compatible protection/deprotection chemistry.

Peptide & delivery

Modification	Type	Purpose / considerations
PNA–peptide conjugates	Delivery / targeting	Cell-penetrating peptides, arginine-rich tails, or NLS motifs.
Arginine-rich / polyarginine tails	Cationic peptide addition	May affect uptake, solubility and nonspecific binding; sequence-specific evaluation.
Cell-penetrating peptide (CPP) conjugates	Delivery peptide	Selected CPP architectures for uptake studies; biological performance not guaranteed.
Nuclear localization signal (NLS) peptides	Targeting peptide	NLS motif attachment for intracellular localization research.
Lipid–PNA conjugates	Hydrophobic conjugation	Cholesterol or fatty-acid attachment by custom route.
Cholesterol–PNA conjugates	Lipid conjugate	Hydrophobic attachment for delivery studies; solubility and purification review.
Fatty-acid–PNA conjugates	Lipid conjugate	Chain-length-dependent attachment and purification considerations.
Cleavable peptide–PNA linkers	Release linker	Stimulus-responsive connection between peptide and PNA; custom review.

Affinity & targeting

Modification	Type	Purpose / considerations
Biotin / digoxigenin	Affinity labels	Capture and immunochemical detection.
Desthiobiotin / affinity variants	Reversible affinity capture	Capture/release concepts assessed for compatible linker chemistry.
PNA–streptavidin capture assemblies	Affinity complex assembly	Biotinylated PNA for streptavidin-mediated capture; validate accessibility and binding.
PNA–antibody conjugates	PNA–protein / antibody conjugation	Previously completed PNA–antibody conjugation projects; evaluate antibody functional groups, conjugation site, loading and retained binding activity.
PNA–biomolecule conjugates	Biomolecular conjugation platform	Custom coupling of PNA to biological macromolecules and functional partners; chemistry, site of attachment and analytical characterization are project-specific.
PNA–plasmid conjugates	PNA–DNA macromolecule conjugation	Previously completed custom PNA–plasmid conjugation projects; plasmid integrity, attachment strategy and product characterization require case-by-case review.
PNA–nanoparticle / surface conjugates	Materials and biosensors	Gold, beads and solid supports via selected reactive handles.
Receptor-targeting ligand conjugates	Targeting conjugate	Ligand selection, attachment site and retained binding must be evaluated.

Advanced architectures

Modification	Type	Purpose / considerations
Bis-PNA / tail-clamp PNA	Multivalent architectures	Linked recognition domains for specialized DNA binding.
Triplex-forming PNA	DNA recognition architecture	Triplex recognition using selected bases and sequence context; binding is target dependent.
Multivalent / branched PNA	Higher-order architecture	Multiple recognition domains and scaffold-linked PNA constructs.
PNA–DNA / PNA–RNA hybrids	Hybrid conjugates	Combined PNA and oligonucleotide functionality.
PNA–drug conjugates	PNA–small-molecule conjugation	Previously completed PNA–drug conjugation projects; linker chemistry, payload stability, purification and identity testing depend on the drug structure.
PNA molecular beacons	Optical probes	Dual-labeled detection constructs.
PNA–nanoparticle / surface conjugates	Materials and biosensors	Gold, beads and solid supports via selected reactive handles.
PNA–plasmid conjugates	PNA–DNA macromolecule conjugation	Previously completed custom PNA–plasmid conjugation projects; plasmid integrity, attachment strategy and product characterization require case-by-case review.
PNA–antibody conjugates	PNA–protein / antibody conjugation	Previously completed PNA–antibody conjugation projects; evaluate antibody functional groups, conjugation site, loading and retained binding activity.
PNA–biomolecule conjugates	Biomolecular conjugation platform	Custom coupling of PNA to biological macromolecules and functional partners; chemistry, site of attachment and analytical characterization are project-specific.
PNA–streptavidin capture assemblies	Affinity complex assembly	Biotinylated PNA for streptavidin-mediated capture; validate accessibility and binding.
PNA–peptide conjugates	Delivery / targeting	Cell-penetrating peptides, arginine-rich tails, or NLS motifs.

This is a research-oriented modification library, not a stocked-reagent list or guarantee of synthesis at every scale. Selected PNA–plasmid, PNA–antibody and PNA–drug conjugations are described as prior custom project experience; new requests require feasibility, attachment-site, purification and QC review. Some constructs appear in multiple categories to support discovery by application.

Purification & characterization

HPLC Purification and Analytical Quality Control

Both standard and modified PNA can be planned with full preparative HPLC purification and fit-for-purpose analytical testing. The final QC package is defined for each order.

Preparative HPLC

Purification of crude PNA using an appropriate chromatographic method, with additional processing as needed for difficult constructs.

Analytical HPLC

Chromatographic purity assessment with a project-specific purity target, method and acceptance criteria.

Mass Spectrometry

Molecular mass confirmation by a suitable MS method, with analytical documentation provided as specified.

Purity Options

Typical quotation targets may include ≥90%, ≥95% or ≥98%, where technically achievable. Higher purity may require additional purification or may not be feasible for certain constructs.

Delivery & Documentation

Lyophilized material, analytical HPLC and mass data, and a Certificate of Analysis may be specified in the quotation. Other testing is evaluated upon request.

Research applications

Applications of Standard & Modified PNA

Choose the research goal first. Dedicated application pages are linked where available; for custom or emerging applications, contact our technical team to discuss the PNA design.

PNA FISH & ISH

Fluorescent PNA probes for cellular localization, chromosome imaging and in situ hybridization.

Explore PNA FISH & ISH →

PCR Clamping & Mutation Analysis

Sequence-selective suppression of wild-type amplification to support mutation enrichment studies.

Explore PCR clamping →

Antisense & Gene Expression

Sequence-directed binding to RNA or DNA for gene-expression and functional research.

Explore antisense oligonucleotides →

Molecular Beacons & Imaging

Fluorophore–quencher PNA designs for hybridization-responsive signal detection.

Explore MGB probe synthesis →

Affinity Capture & Plasmid Targeting

Biotinylated bis-PNA and triplex-forming PNA designs for sequence-specific plasmid recognition, streptavidin-mediated capture, immobilization and conjugate assembly.

Explore Bis-PNA Synthesis →

Biotin & streptavidin capture chemistry →

Biosensors & Peptide Delivery

PNA probe immobilization and peptide–PNA conjugates for detection or delivery studies.

Explore peptide–PNA conjugation →

Explore the PNA service platform

Related PNA Synthesis & Conjugation Services

Explore specialized synthesis chemistry and conjugation platforms. Application-specific probe pages are linked above, so they are not repeated here.

Backbone modification

γ-PNA & Backbone Engineering

Gamma-modified PNA and advanced backbone designs, subject to monomer and feasibility review.

Explore γ-PNA synthesis →

Integrated synthesis

Peptide–PNA Conjugation

Peptide attachment, linker design, purification and conjugate characterization.

Explore peptide–PNA conjugation →

Advanced conjugation

PNA–Biomolecule Conjugation

Custom PNA–antibody, PNA–plasmid and PNA–drug conjugation projects; attachment strategy reviewed individually.

Explore biomolecule conjugation →

Triplex & sequence recognition

Bis-PNA & Triplex PNA

Linked PNA recognition domains and triplex-forming constructs for sequence-specific DNA targeting, plasmid binding and affinity-capture research.

Explore Bis-PNA & Triplex PNA →

Branched & multivalent architectures

Complex PNA Conjugates & Multivalent PNA

Custom branched, multivalent and multifunctional PNA architectures, including engineered scaffolds and complex PNA conjugates for recognition, capture and delivery research.

Explore complex PNA conjugates →

Imaging probes

Custom PNA FISH & ISH Probes

Fluorescently labeled PNA probe synthesis for in situ hybridization, chromosome and cellular imaging applications.

Explore PNA FISH & ISH →

From sequence to shipment

Custom PNA Synthesis Workflow

01 / REVIEW

Sequence & Feasibility

Review length, composition, modifications and raw materials.

02 / SYNTHESIS

PNA Assembly

Prepare standard or modified PNA by a selected synthetic route.

03 / PURIFICATION

Preparative HPLC

Purify and recover the desired PNA product.

04 / QC & DELIVERY

HPLC / MS

Confirm project-defined identity and purity specifications.

CUSTOM PNA SYNTHESIS · CONTACT & QUOTE

Ready to synthesize your standard or modified PNA?

From small-scale research probes to larger custom synthesis projects, share your PNA sequence, desired modifications, synthesis scale or purified yield, purity target and application. Our team can review chemistry, HPLC purification and mass spectrometry QC requirements.

Request a Quote → Discuss with a Scientist ↗

Standard & Modified PNA Research to Custom Bulk Scale HPLC + MS QC

Need Technical Guidance?

Discuss standard PNA, γ-PNA, modified nucleobases, fluorescent labels, linkers, conjugates and scale-up feasibility.

Fast Quote Checklist

Include PNA sequence (N→C), modification positions, required quantity, HPLC purity, analytical QC and delivery format.

Request Quote →

PNA Synthesis FAQs

FAQ

Can you synthesize γ-PNA or modified-base PNA?

Selected γ-PNA and modified-base designs can be evaluated. Feasibility depends on monomer structures, availability and the requested sequence.

What is the difference between standard and modified PNA?

Standard PNA uses conventional nucleobases on the PNA backbone. Modified PNA incorporates additional labels, functional groups, modified monomers, conjugates or engineered backbone chemistry.

Can standard PNA be HPLC purified?

Yes. Preparative HPLC can be specified for standard PNA, followed by analytical HPLC and mass spectrometry as defined in the quotation.

Can modified PNA also be purified by HPLC?

Many modified PNA constructs can be HPLC purified, but method suitability, recovery and attainable purity depend on the modifications and sequence.

What purity can I request?

Targets such as ≥90%, ≥95% or ≥98% may be quoted where achievable. Actual acceptance criteria are agreed for each project.

Does 100 nmol synthesis scale mean 100 nmol delivered?

No. Nominal synthesis scale is distinct from the final purified amount. Request a guaranteed final yield if your application requires one.

Can I add a fluorescent dye or biotin?

Yes, compatible terminal or side-chain labeling strategies may be evaluated, including fluorescent and affinity labels.

What information is needed for a quote?

Provide the PNA sequence in N-to-C orientation, modification positions, intended use, synthesis scale or final purified quantity, purity target and QC requirements.

More FAQs All FAQs

PNA in peer-reviewed research

Selected PNA Synthesis Publications & Research

Explore selected peer-reviewed studies demonstrating PNA technologies, including antisense applications, peptide–PNA conjugates, triplex-forming PNA, and fluorescence imaging. These references illustrate research applications and do not necessarily indicate that Bio-Synthesis supplied the materials used.

Triplex & Tail-Clamp

Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids

Tail-clamp PNA with lysine termini and flexible linkers. Methods explicitly name Bio Synthesis Inc. as the manufacturer.

Supplier explicitly identified

Read publication ↗

Standard PNA & Antisense

Disrupting Protein Expression with Peptide Nucleic Acids Reduces Infection by Obligate Intracellular Rickettsia

Antisense PNA used to suppress bacterial protein expression. Supplier attribution requires final source check.

Supplier attribution to confirm

Read publication ↗

Peptide–PNA Conjugates

Peptide Nucleic Acid Antisense Oligomer as a Therapeutic Strategy against Bacterial Infection

Unmodified and peptide-conjugated PNA evaluated in bacterial infection research. Supplier attribution requires final source check.

Supplier attribution to confirm

Read publication ↗

Peptide–PNA Conjugates

Pharmacokinetic Analysis of PNA–Cell Penetrating Peptide Conjugates

Pharmacokinetics of peptide–PNA constructs; useful technical context for conjugate engineering.

Supplier attribution to confirm

Read publication ↗

Triplex & Tail-Clamp

Correction of F508del CFTR in Airway Epithelium Using Nanoparticles Delivering Triplex-Forming PNAs

Triplex-forming PNA delivery for sequence-directed gene correction. Multiple possible suppliers are reported.

Multiple suppliers / review attribution

Read publication ↗

PNA FISH & Imaging

TERRA, hnRNP A1, and DNA-PKcs Interactions at Human Telomeres

Telomere imaging research involving labeled PNA probes.

Supplier attribution to confirm

Read publication ↗

PNA FISH & Imaging

Molecular Insights into the Heterogeneity of Telomere Reprogramming

Fluorescent telomeric PNA probe use in chromosome research.

Supplier attribution to confirm

Read publication ↗

PNA FISH & Imaging

SLX4IP Acts in Parallel to FANCM to Limit BLM-Dependent Replication Stress at ALT Telomeres

Fluorescent PNA telomere imaging in alternative lengthening of telomeres research.

Supplier attribution to confirm

Read publication ↗

The CCR5 study explicitly identifies Bio Synthesis Inc. as a PNA supplier in its methods. Other references are included for scientific relevance; Bio-Synthesis supplier attribution has not been established for those studies. Specialized modifications and custom constructs remain subject to project-specific feasibility review.

Why Choose Bio-Synthesis

Trusted by biotech leaders worldwide for over 45 years of delivering high-quality, fast, and scalable synthetic biology solutions.

Standard & Modified PNA Synthesis

Custom PNA Synthesis. From Discovery to Scale.

Start small. Scale with your research.

25–100 nmol

250–500 nmol

1–10 nmol

Bulk requests

Two PNA Synthesis Options

Standard PNA Synthesis

Modified PNA Synthesis

Proposed PNA Synthesis Scales & Custom Yield Options

Nominal Synthesis Scales

Purified Milligram & Bulk Orders

Explore PNA Modification Options

Backbone & structural

Modified nucleobases

Terminal modifications

Fluorescent labels

Quenchers & optical

Spacers & linkers

Reactive handles

Peptide & delivery

Affinity & targeting

Advanced architectures

HPLC Purification and Analytical Quality Control

Preparative HPLC

Analytical HPLC

Mass Spectrometry

Purity Options

Delivery & Documentation

Applications of Standard & Modified PNA

PNA FISH & ISH

PCR Clamping & Mutation Analysis

Antisense & Gene Expression

Molecular Beacons & Imaging

Affinity Capture & Plasmid Targeting

Biosensors & Peptide Delivery

Related PNA Synthesis & Conjugation Services

γ-PNA & Backbone Engineering

Peptide–PNA Conjugation

PNA–Biomolecule Conjugation

Bis-PNA & Triplex PNA

Complex PNA Conjugates & Multivalent PNA

Custom PNA FISH & ISH Probes

Custom PNA Synthesis Workflow

Sequence & Feasibility

PNA Assembly

Preparative HPLC

HPLC / MS

Ready to synthesize your standard or modified PNA?

Need Technical Guidance?

Fast Quote Checklist

PNA Synthesis FAQs

FAQ

Selected PNA Synthesis Publications & Research

Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids

Disrupting Protein Expression with Peptide Nucleic Acids Reduces Infection by Obligate Intracellular Rickettsia

Peptide Nucleic Acid Antisense Oligomer as a Therapeutic Strategy against Bacterial Infection

Pharmacokinetic Analysis of PNA–Cell Penetrating Peptide Conjugates

Correction of F508del CFTR in Airway Epithelium Using Nanoparticles Delivering Triplex-Forming PNAs

TERRA, hnRNP A1, and DNA-PKcs Interactions at Human Telomeres

Molecular Insights into the Heterogeneity of Telomere Reprogramming

SLX4IP Acts in Parallel to FANCM to Limit BLM-Dependent Replication Stress at ALT Telomeres

Why Choose Bio-Synthesis

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