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Bio-Synthesis, Inc. Launches Peptide Library Generation Tools Software


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- Custom Carbohydrates

Custom LNA

(Lock Nucleic Acid Synthesis), Locked Nucleic Acid (LNA) was first described by Wengel and co-workers in 1998 as a novel class of conformationally restricted oligonucleotide analogues. LNA is a bicyclic nucleic acid where a ribonucleoside is linked between the 2'-oxygen and the 4'-carbon atoms via a methylene unit.

Oligonucleotides containing LNA exhibit unprecedented thermal stability towards complementary DNA and RNA2, which allows excellent mismatch discrimination. In fact, the high binding affinity of

LNA oligos

is recommended for use in any hybridization assay that requires high specificity and/or reproducibility such as

	Dual labeled probes
	In situ hybridization probe
	SNP genotyping
	DNA MicroArray expression analysis
	Allele Specific PNA
	mRNA sample preparation
	Molecular Beacons and PCR primers

As a result of these significant characteristics, the use of LNA-modified oligos in antisense drug development is now coming under investigation⁴ and, recently, the therapeutic potential of LNA has been reviewed.⁵

BSI offers LNA synthesis with great flexibility. For more information on

custom LNA synthesis

, call 800-227-0627 or write to us at biosyn@biosyn.com


LNA Synthesis	LNA Modification	Dual Labeled Probes
LNA Conjugations	LNA Chimeras

Deprotected, desalted and ready to use

Multi-scale capacities

Purification by PAGE or RP-HPLC upon request

QC analysis by MALDI-TOF Mass spectrometry, HPLC, PAGE analysis

Fast delivery with high throughput capacity

References:
(1a) A.A. Koshkin, S.K. Singh, P. Nielsen, V.K. Rajwanshi, R. Kumar, M. Meldgaard, C.E. Olsen, and J. Wengel, Tetrahedron,1998, 54, 3607-3630.
(1b) S.K. Singh, P. Nielsen, A.A. Koshkin, and J. Wengel, Chem. Comm., 1998, (4), 455-456.
(2) L. Kværnø and J. Wengel, Chem. Comm., 1999, (7), 657-658.
(3) P. Mouritzen, A.T. Nielsen, H.M. Pfundheller, Y. Choleva, L. Kongsbak, and S. Møller, Expert Review of Molecular Diagnostics, 2003, 3(1), 27-38.
(4a) J. Kurreck, E. Wyszko, C. Gillen, and V.A. Erdmann, Nucleic Acids Res., 2002, 30, 1911-1918.
(4b)H. Ørum and J. Wengel, Curr. Opinion in Mol. Therap., 2001, 3, 239-243.
(5a) M. Petersen and J. Wengel, Trends in Biotechnology, 2003, 21(2), 74-81.
(5b) D.A. Braasch, D.R. Corey, Biochemistry, 2002, 41, 4503-4510.

The most trusted name in Quality Custom Synthesis.