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Do you provide oligonucleotide-folate conjugates

Bio-Synthesis provides Oligonucleotide-folate conjugates by covalently attach folic acid to 5' or 3' end of an oligonucleotide. While covalent conjugation of nucleic acids to various functional molecules has been widely studied to improve cell-specific targeting and delivery  of oligonucleotide for sequence specific modulation of gene expression. Studies have shown that the covalent atachment of folic acid to an oligonucletoide produces a conjugate capable of internalization into folate receptor-bearing cells similar to that of the free folic acid. Such approach enable the enhancement of cell uptake of oligonculetoides to exploit the active transport mechanism of receptor-mediated endocytosis.

Contact Bio-Synthesis for oligo folate conjugation services.

Reference:
  1. Gait, M.J. Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues. Cell. Mol. Life Sci. 2003 , 60, 844–853.
  2. Matulic-Adamic, J.; Serebryany, V.; Haeberli, P.; Mokler, V.R.; Beigelman, L. Synthesis of N -acetyl-d- galactosamine and folic acid conjugated ribozymes. Bioconjugate Chem . 2002 , 13, 1071–1078.