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Definition

Bacterial peptides are protein fragments which are either part of a bacterium or produced by a bacteria1.

 

Classification

Different classes of peptides are produced by bacteria. Some examples include, antibiotics, enterotoxins, flagellar proteins, lipoproteins and various enzymes1.

 

Structural Characteristics

Structural characteristics of some bacterial peptides are described below-

A)      Malaria merozoite surface peptide (MSP-1): It is synthesized as a large precursor on the surface of the bacterium Plasmodium falciparum.  Proteolytic cleavage results in the production of a 19 KDa product whose tertiary structure is maintained by disulphide bridges2.

B)     Giardia variable surface protein: This peptide is the specific conserved region of the Giardia variable surface proteins (VSPs) that are cysteine rich zinc finger proteins. VSPs differ in size and sequence, they are characterized by this highly conserved C-terminal membrane spanning region, a hydrophilic cytoplasmic tail with a conserved five amino acid CRGKA signature sequence3,4.

C)    P.falciparum liver stage antigen 3: The protein is 200Kda and is highly conserved among parasites from different geographic regions5.

 

Mode of action

A)     MSP-1 is known to trigger antibody response by CD4 helper T cells. It is likely that these cells bind to the C-terminal domain of MSP-12.

B)     VSPs have a conserved hydrophilic amono acid trail that is palmitoyted by palmityl tranferases upon which they are activated3,4.

C)    P. falciparum liver stage antigen 3 is a potent antigen that is recongnized by T cells5.

 

Functions

A)     MSP-1 is a vaccine candidate for Plasmodium falciparum infection. It triggers a CD-4 T cell response2.

B)     VSPs are necessary for survival in the environment and host infection3,4.

C)    P.falciparum stage antigen 3 is also a good candidate vaccine as it activates both T and B cell responses5.

 

 

References

 

1.     Gitai Z (2005). "The new bacterial cell biology: moving parts and subcellular architecture". Cell, 120 (5): 577–86.

2.     Stuart JQ and Jean L (2001). Different regions of the malaria merozoite surface protein 1 of Plasmodium chabaudi elicit distinct T-cell and antibody isotype responses. Infect Immun, 69(4): 2245–2251.

3.     Davids BJ, Reiner DS, Birkeland SR, Preheim SP, Cipriano MJ, McArthur AG, Gillin FD (2006). A New Family of Giardial Cysteine-Rich Non-VSP Protein Genes and a Novel Cyst Protein. PLoS ONE, 20,1:e44.

4.     Touz MC, Conrad JT, Nash TE (2005). A novel palmitoyl acyl transferase controls surface protein palmitoylation and cytotoxicity in Giardia lamblia. Mol Microbiol., 58 (4), 999-1011.

5.     Jean-Pierre S, Blanca LP, Karima B, Pierra D, Pierra D (2001). DNA Immunization by Plasmodium falciparum liver-stage antigen 3 induces protection against Plasmodium yoelii Sporozoite challenge. Infect Immun., 69, 1202–1206.

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If you are unable to find your desired product please contact us for assistance or send an email to info@biosyn.com

 
Product Name Catalog # Unit Price/Unit 
Bactenecin, bovine
RLCRIVVIRVCR (Disulfide bridge: 3-11)
10454-01 1 mg $295 cart inquire
Bactenecin bovine
RLCRIVVIRVCR (Disulfide bridge: 3 - 11)
10454-005 0.5 mg $171 cart inquire
Bacterial Sortase Substrate I, FRET
DABCYL - LPETG - EDANS
14285-01 1 mg $232 cart inquire
Bacterial Sortase Substrate II Dabcyl/Edans
Dabcyl - QALPETGEE - Edans
14286-01 1 mg $259 cart inquire
Bacterial Sortase Substrate III Abz/DNP
Abz - LPETG - K(Dnp) - NH2
14287-01 1 mg $232 cart inquire
CFP10 (71–85)
EISTNIRQAGVQYSR
10462-01 1 mg $120 cart inquire
CFTR (108 - 117), Pseudomonas aeruginosa Inhibitor
SYDPDNKEER
10463-01 1 mg $215 cart inquire
Competence Stimulating Peptide-1, CSP-1
EMRLSKFFRDFILQRKK
14255-01 1 mg $120 cart inquire
Competence-stimulating peptide -2, CSP-2
EMRISRIILDFLFLRKK
14256-01 1 mg $120 cart inquire
CRGKA, Giardia Variable Surface Proteins Conserved
CRGKA
10466-01 1 mg $50 cart inquire
flg22, Flagellin Fragment
QRLSTGSRINSAKDDAAGLQIA
14288-01 1 mg $176 cart inquire
HCAM - 2
6 - FAM - VFDAVTDVIIKNNLKECGLY
14289-01 1 mg $298 cart inquire
Lethal Factor (LF) Inhibitor Anthrax related
MKARRKKVYP- NHOH
10453-01 1 mg $260 cart inquire
LF 20 Consensus Peptide. Anthrax Related Lethal Fa
MLARRKKVYPYPMEPTIAEG-CONH2
10452-01 1 mg $310 cart inquire
Listeria monocytogenes Listeriolysin O; LLO (91 - 99)
GYKDGNEYI
14284-01 1 mg $120 cart inquire
MSP - 1 (20 - 39), Merozoite Surface Peptide 1
VTHESYQELVKKLEALEDAV
10457-01 1 mg $250 cart inquire
MSP - 1 P2, Malaria Merozoite Surface Peptide - 1
GYRKPLDNIKDNVGKMEDYIKK
10455-01 1 mg $300 cart inquire
MSP - 1 P3, Malaria Merozoite Surface Peptide - 1
KLNSLNNPHNVLQNFSVFFNK
10456-01 1 mg $295 cart inquire
Mycobacterium tuberculosis Protein Ag85A
LTSELPGWLQANRHVKPTGS
10468-01 1 mg $100 cart inquire
Mycobacterium Tuberculosis Protein Ag85A - CD8
MPVGGQSST
10467-01 1 mg $210 cart inquire
N - 10 Region of TRAP
DEIKYSEEVC
10451-01 1 mg $230 cart inquire
P38 (411 - 425), M. leprae
AGGGVTLLQAAPALD
10458-01 1 mg $240 cart inquire
P61 (343 - 355), M. leprae
RVAQIRTEIENSD
10459-01 1 mg $225 cart inquire
P62 (417 - 429), M. leprae
LLQAAPALDKLKL
10460-01 1 mg $225 cart inquire
P69 (522 - 534), M. leprae
PEKTAAPASDPTG
10461-01 1 mg $225 cart inquire
P. falciparum Liver - Stage Antigen 3 - NRII (LSA3 - NRII)
LEESQVNDDIFNSLVKSVQQEQQHNV
10469-01 1 mg $335 cart inquire
PyCSP (57–70) Plasmodium Yoelii Circumsporozoite P
KIYNRNIVNRLLGD
10464-01 1 mg $220 cart inquire
SKIGKV - NH2
SKIGKV-CONH2
10450-01 1 mg $270 cart inquire
SPase I FRET Substrate
Dabcyl - AGHDAHASET - Edans
14290-01 1 mg $188 cart inquire
Staphylococcal Enterotoxin B Domain (SEB) (144 - 153)
KKKVTAQELD
14291-01 1 mg $120 cart inquire

Biosynthesis Inc.