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Definition

The CEF control peptides are 8-12 amino acids in length, with sequences derived from the human Cytomegalovirus, Epstein-Barr Virus and Influenza Virus1 These peptides are used in the stimulation of IFNg release from CD8+ T cells in individuals with defined HLA types1.  They are useful as positive control peptides in several cytokine assays such as Elispot.

Discovery

CEF peptides were first selected in 2002 based on their ability to recognize CD8+ T cells1.

Classification

They are derived from epitopes of viruses and hence have antigenic properties1.

Structural Characteristics

CEF peptides are 8-11 amino acids long with sequences: GILGFVFTL (Influenza A, HLA-A2), FMYSDFHFI (Influenza A, HLA-A2), CLGGLLTMV (EBV, HLA-A2), GLCTLVAML (EBV, HLA-A2), NLVPMVATV (HCMV, HLA-A2).

Mode of action

CEF peptides are effective epitopes for CD8+ T cells2.  They bind to these cells and trigger the production of IFNg.

Functions

CEF control peptides are used as positive control in Elispot assay that is used to investigate specific immune responses in various diseases including infections, cancer, allergies and autoimmune diseases2.  In this case the CEF peptides ensure that the cells under study are active and viable2.  Elispot is also useful in the development of vaccines especially for HIV where CEF peptides are used also as controls2.

References
 

1.     Currier JR, Kuta EG, Turk E, Earhart LB, Loomis-Price L, Janetzki S, Ferrari G, Birx DL, Cox JH (2002). A panel of MHC class I restricted viral peptides for use as a quality control for vaccine trial ELISPOT assays, J Immunol Methods, 260, 157-172.

2.     Gazagne A, Claret E, Wijdenes J, Yssel H, Bousquet F, Levy E, Vielh P, Scotte F, Goupil T, Fridman WH, Tartour E (2003). A Fluorospot assay to detect single T lymphocytes simultaneously producing multiple cytokines, J Immunol Methods, 283(1-2), 91-98.

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If you are unable to find your desired product please contact us for assistance or send an email to info@biosyn.com

 
Product Name Catalog # Unit Price/Unit 
CEF10, Epstein - Barr Virus LMP2 (426 - 434)
CLGGLLTMV
10821-01 1 mg $120 cart inquire
CEF11 Epstein - Barr Virus BMLF1 (280 - 288)
GLCTLVAML
10822-01 1 mg $120 cart inquire
CEF12, Epstein - Barr Virus latent NA3B (399 - 408)
AVFDRKSDAK
10823-01 1 mg $125 cart inquire
CEF14, Epstein - Barr Virus Rta Protein (28 - 37)
DYCNVLNKEF
10824-01 1 mg $125 cart inquire
CEF15, Epstein - Barr Virus Lytic Cycle Protein BZLF - 1 (190-197)
RAKFKQLL
10825-01 1 mg $125 cart inquire
CEF16, Epstein - Barr Virus latent NA - 3A (337 - 347)
FLRGRAYGL
10826-01 1 mg $125 cart inquire
CEF17, Epstein - Barr Virus latent NA - 3A (158 - 166)
QAKWRLQTL
10827-01 1 mg $125 cart inquire
CEF18, Epstein - Barr Virus latent NA - 3C (258 - 266)
RRIYDLIEL
10828-01 1 mg $125 cart inquire
CEF19 Epstein - Barr Virus latent NA - 3A (458 - 466)
YPLHEQHGM
10829-01 1 mg $120 cart inquire
CEF1, Influenza Matrix Protein M1 (58 - 66)
GILGFVFTL
10812-01 1 mg $120 cart inquire
CEF20 Cytomegalovirus, CMV pp65 (495 - 503)
NLVPMVATV
10830-01 1 mg $120 cart inquire
CEF21, Cytomegalovirus, CMV pp65 (417 - 426)
TPRVTGGGAM
10831-01 1 mg $125 cart inquire
CEF22, Cytomegalovirus, CMV pp65 (378 - 389)
SDEEEAIVAYTL
10832-01 1 mg $125 cart inquire
CEF23, Cytomegalovirus, CMV pp65 (123 - 131)
IPSINVHHY
10833-01 1 mg $125 cart inquire
CEF24, Influenza Virus PB1 Peptide (591 - 599)
VSDGGPNLY
10834-01 1 mg $125 cart inquire
CEF25 Influenza Virus NP (44 - 52)
CTELKLSDY
10835-01 1 mg $120 cart inquire
CEF26 Influenza Virus NP (265 - 274)
ILRGSVAHK
10836-01 1 mg $120 cart inquire
CEF27, Epstein - Barr Virus BRLF - 1 lytic (148 - 156)
RVRAYTYSK
10837-01 1 mg $125 cart inquire
CEF28, Epstein - Barr Virus latent NA - 3A (603 - 611)
RLRAEAQVK
10838-01 1 mg $125 cart inquire
CEF29, Epstein - Barr Virus latent NA - 3B (416 - 424)
IVTDFSVIK
10839-01 1 mg $125 cart inquire
CEF2, Influenza Virus PA (46 - 54)
FMYSDFHFI
10813-01 1 mg $120 cart inquire
CEF30 Epstein - Barr Virus BRLF1 (134 - 142)
ATIGTAMYK
10840-01 1 mg $120 cart inquire
CEF31, Epstein - Barr Virus latent NA - 3A (379 - 387)
RPPIFIRRL
10841-01 1 mg $125 cart inquire
CEF32, Epstein - Barr Virus latent NA - 3C (281 - 290)
EENLLDFVRF
10842-01 1 mg $125 cart inquire
CEF33, Cytomegalovirus, HCMV pp65
EFFWDANDIY
10843-01 1 mg $125 cart inquire
CEF3, Influenza Virus M1 (13 - 21)
SIIPSGPLK
10814-01 1 mg $125 cart inquire
CEF4, Influenza Virus NP (342 - 351)
RVLSFIKGTK
10815-01 1 mg $125 cart inquire
CEF5, Influenza Virus NP (91 - 99)
KTGGPIYKR
10816-01 1 mg $125 cart inquire
CEF6, Influenza Virus NP
LPFDKTTVM
10817-01 1 mg $125 cart inquire
CEF7, Influenza Virus NP (380 - 388)
ELRSRYWAI
10818-01 1 mg $125 cart inquire
CEF8, Influenza Virus NP (383 - 391)
SRYWAIRTR
10819-01 1 mg $120 cart inquire
CEF9, Influenza Virus M1 128 - 135
ASCMGLIY
10820-01 1 mg $125 cart inquire
CEF Class I - 32 Control Peptide Libraries and Pools
13686-16 16 mg $1,250 cart inquire
CEF Class I - 32 Control Peptide Pool
13686-08 8 mg $750 cart inquire
CEF Control Peptide Pool
14347-01 1 mg $120 cart inquire
CEF Control Peptide Pool HLA-A2 (2.5 mgs)
13690-025 2.5 mgs $395 cart inquire
CEF Control Peptide Pool HLA-A2 (5.0 mgs)
13690-05 N/A $575 cart inquire
CEF Control Peptide Pool HLA-A24 (0.5 mgs)
13691-04 N/A $375 cart inquire
CEF Control Peptide Pool HLA-A24 (1 mg)
13691-08 N/A $630 cart inquire
Cytomegalovirus (CMV) Control Peptide Pool
13687-05 5 mg $575 cart inquire
Cytomegalovirus (CMV) Control Peptides Pools (2.5 mgs size)
13687-025 2.5 mg $295 cart inquire
Epstein - Barr Virus (EBV) Control Peptide Pool
13688-075 7.5 mg $720 cart inquire
Epstein - Barr Virus (EBV) Control Peptide Pool 13688-15
13688-15 15 mg $1,150 cart inquire
Influenza Virus Control Peptide Pool
14348-03 3 mg $418 cart inquire
Influenza Virus Control Peptide Pool (13689-06)
13689-06 6 mg $595 cart inquire
Influenza Virus Control Peptide Pool (13689-12)
13689-12 12 mg $1,050 cart inquire

Biosynthesis Inc.