Live Chat Support Software
800.227.0627

Definition

Cell adhesion peptides are peptides that promote adhesion of normal and tumor cells and are derived from extracellular matrix glycoproteins such as laminin, fibronectin and collagen1.

Discovery

Synthetic cell adhesion peptides were first derived from laminin. The peptide PA22-2 (CSRARKQAASIKVAVSADR-NH2) derived from laminin was found to function as a cell adhesion molecule which was tested with mouse mast cells1.

Classification

Cell adhesion peptides for the most part are extracellular matrix proteins1.

Structural Characteristics

Numerous cell adhesion peptides have been synthesized to date.  Some examples include: RU-1 (LNIVSVNGRHX), RX-1 (DNRIRLQAKXX), GD-1 (KATPMLKMRTSFHGCIK), GD-2 (KEGYKVRLDLNITLEFRTTSK), GD-3 (KNLEISRSTFDLLRNSYGVRK), GD-6 (KQNCLSSRASFRGCVRNLRLSR), HGD-6 (KQKCLRSQTSFRGCLRKLALIK), SGD-6 (CRNRGRCNSSLFQVRSRKLLSA), HSGD-6 (KQCLKSQRSFTRGLCRLKAKIL), AG-1 (KLLISRARKQÁASIK), F17 (LERKYENDQKYLEDKA) and KRGD (VEKRGDREEA).  Peptides that are linear and cyclic in nature have been synthesized2.

Mode of action

Cell adhesion peptides can bind to the cell membrane and trigger adhesion of cells3.

Functions

Cell adhesion peptides have known to increase signaling via receptors3.  They have been shown to decrease tumor metastasis and growth in experimental animals3.  These peptides also induce Ca2+ signaling and modulate platelet activity3.

References

 

1.     Thompson HL, Burbelo PD,Yamada Y,Kleinman HK and Metcalfe DD (1991). Identification of an amino acid sequence in the laminin A chain mediating mast cell attachment and spreading, Immunology, 72, 144-149.

2.     Gehlsen KR, Sriramarao P, Furcht LT and Skubitzt APN (1992).  A Synthetic Peptide Derived from the Carboxy Terminus of the Laminin A Chain Represents a Binding Site for the a3ß1 Integrin, J Cell Biology,117 (2), 449-459.

3.     Book: Proteins analysis and design, Angeletti RH, 222-226.

ALL
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z

If you are unable to find your desired product please contact us for assistance or send an email to info@biosyn.com

 
Product Name Catalog # Unit Price/Unit 
37 40 GAP26Connexin Mimetic
VCYDQAFPISHIR
14350-01 1 mg $120 cart inquire
3743Gap 27 Connexin Mimetic
SRPTEKTIFII
14349-01 1 mg $120 cart inquire
40Gap 27 Connexin Mimetic
SRPTEKNVFIV
14351-01 1 mg $120 cart inquire
43Gap 26 Connexin Mimetic
VCYDKSFPISHVR
14352-01 1 mg $120 cart inquire
4N1K
KRFYVVMWKK
14353-01 1 mg $120 cart inquire
αB - Crystallin (73 - 92)
DRFSVNLDVKHFSPEELKVK
10849-01 1 mg $250 cart inquire
Bacterial Sortase Substrate I FRET
DABCYL - LPETG - EDANS
14354-01 1 mg $232 cart inquire
Cell Adhesive Peptide [RGDC]
RGDC
14355-01 1 mg $120 cart inquire
FN - A208 Fusion Peptide
GRGDSGAASIKVAVSADR
14356-01 1 mg $120 cart inquire
Gap 27 scrambled
REKIITSFIPT
14357-01 1 mg $120 cart inquire
Hyaluronan - Binding Peptide biotin labeled
GAHWQFNALTVRGGGS - K(Biotin)
14359-01 1 mg $132 cart inquire
Hyaluronan Inhibitor
GAHWQFNALTVR
14358-01 1 mg $120 cart inquire
L1CD cell adhesion molecule (1144–1163)
KRSKGGKYSVKDKEDTQVDS
10846-01 1 mg $250 cart inquire
L1FLCD (1173 - 1185)
FGEYRSLESDNEE
10845-01 1 mg $220 cart inquire
pALA, Polyalanine Peptide
AAADAAAAL
10847-01 1 mg $220 cart inquire
S1P1
VSTSIPEVKALRSSVSDYGNYDIIVRHYNYTGKLNIGAEKDHGIK
10850-005 0.5 mg $350 cart inquire
Thrombospondin - derived Peptide Cyclic CSVTCG -14360-01
CSVTCG (S - S Bonded)
14360-01 1 mg $120 cart inquire
Vitronectin (367 - 378)
GKKQRFRHRNRKG
14361-05 5 mg $320 cart inquire

Biosynthesis Inc.