Hydrocarbon - Stapled Helix SAHBA Peptide
Hydrocarbon - Stapled Helix SAHBA Peptide
Sequence (1LC):
EDIIRNIARHLAXVGDX-Nle-DRSIW-CONH2 (with special cyclization to get double bond, X= (S)-2-(2’-pentenyl)alanine)
Sequence (3LC):
NH2 - Glu - Asp - Ile - Ile - Arg - Asn - Ile - Ala - Arg - His - Leu - Ala - X - Val - Gly - Asp - X - Nle - Asp - Arg - Ser - Ile - Trp -CONH2 X = (S) - 2 - (2’ - pentenyl)Ala (with special cyclization to get the double bond)
Price/Unit:
$1,638
(For other quantities please
Contact Us or call 972-420-8505 (USA) 800-227-0627 (INTL.) or Fax 972.420.0442)
Format:
Each vial contains lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt
Description:
SAHBA peptide targets the binding pocket of BCL-XL. It exhibits enhanced BCL-2 binding affinity specifically activating cytochrome c release from mitochondria in vitro and suppresses growth of human leukemia cells in vivo, prolonging the survival of leukemic mice.
Storage:
Store the peptide at -20°C. Keep container tightly
Product Usage:
This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Reference/Citations:
Welensky, LD. et al. Science 305, 1466 (2004).
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