α-Tocopherol-TEG, vitamin E, is a lipophilic and non-toxic compound that can be chemically incorporated at any position within an oligonucleotide. In order to penetrate cell membranes and improve celluar uptake, it is often necessary to conjugate therapeutic oligonculetoides with non-toxic, lipophilic molecules. Cholesteryl TEG, alpha-tocopherol, GalNAc, and stearyl labelling of oligonucleotides have proven to be useful in delivering oligonucleotides
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-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.
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