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A Collection of Peptide Nutraceuticals

A Collection of Peptide Nutraceuticals

Peptide nutraceuticals are peptide-based health supplements derived from proteins. Unlike standard protein powders that require digestion, these peptides are already partially broken-down proteins, usually consisting of 2 to 50 amino acid residues. Because of their smaller size, they are highly bioactive and are quickly absorbed by the human body. When a regular protein, for example when eating a steak, is consumed, the digestive system breaks it down into individual amino acids. Peptide nutraceuticals bypass the major digestive steps and may act as biological messengers. Some of these peptides can enter the bloodstream intact, resisting destruction by digestive enzymes. Once absorbed, they bind to specific receptors on cells, potentially "switching on" processes like collagen production, immune defense, or muscle repair.

Here is a list of Peptide Nutraceuticals

Source

Peptide

Function

Reference

 

From Faba Bean: NPN_1

HLPSYSPSPQ

Phosphorylation on S6 stimulates muscle growth.

Corrochano AR, Cal R, Kennedy K, Wall A, Murphy N, Trajkovic S, O'Callaghan S, Adelfio A, Khaldi N. Characterising the efficacy and bioavailability of bioactive peptides identified for attenuating muscle atrophy within a Vicia faba-derived functional ingredient. Curr Res Food Sci. 2021 Apr 3;4:224-232. [PMC]

 

TIKIPAGT

Anti-inflammatory by inhibiting TNF-alpha.

Evolv life

Neutraceuticals World

Cu-GHK and marine collagen peptides.

Oral hair growth supplement. Marine collagen peptides contain hydrolyzed Type I and III collagen derived from fish scales or skins.

Rahman A, Rehmani R, Pirvu DG, Huang SM, Puri S, Arcos M. Unlocking the Therapeutic Potential of Marine Collagen: A Scientific Exploration for Delaying Skin Aging. Mar Drugs. 2024 Mar 30;22(4):159.  [PMC]

Casein, fermented milk.

LNDP; NIPPLTQTPVVVPPFLQPE

Lactonona-decapeptide, a casein-derived peptide comprising 19 residues, is known for its capacity to enhance cognitive function.

Nakatani E, Sasai M, Miyazaki H, Tanaka S, Hirota T, Okura T. Investigating the Transepithelial Transport and Enzymatic Stability of Lactononadecapeptide (NIPPLTQTPVVVPPFLQPE), a 19-Amino Acid Casein-Derived Peptide in Caco-2 Cells. J Agric Food Chem. 2024 Jun 5;72(22):12719-12724. [PMC]

Milk casein

Alpha-Casozepine (alpha-CZP)

YLGYLEQLLR

An anxiolytic-like bioactive decapeptide, is a tryptic hydrolysate of bovine milk alphas1-casein. Promotes sleep.

Manna, S.S.S.: Possible influence of neurosteroids in the anxiolytic effects of alpha-casozepine. Medical Hypotheses, Volume 155, 2021, 110655. [Sciencedirect]

Synthetic, original from gastric juice.

BP-157 (Body Protective Compound-157)

GEPPPGKPADDAGLV

BPC-157 demonstrates robust regenerative and cytoprotective effects in preclinical studies, positioning it as a potentially valuable tool in musculoskeletal medicine.

McGuire FP, Martinez R, Lenz A, Skinner L, Cushman DM. Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing. Curr Rev Musculoskelet Med. 2025 Dec;18(12):611-619. [PMC]

Thymosin β4.

TB-500:

Thymosin beta

Ac-LKKTETQ

Claimed to promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition and decrease inflammation.

Ho EN, Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2012 Nov 23;1265:57-69. [PubMed]

 

Casein

Casein Hydrolysate Containing

VPP and IPP

Muscle Pump, Muscle Hyper-trophy, a unique contributor to nitric oxide production resulting in healthy blood flow, stamina, lean muscle growth, and motivation.

Effects of Casein Hydrolysate Containing Val-Pro-Pro and Ile-Pro-Pro on Muscle Pump, Muscle Hypertrophy, and Motivation in Resistance-Trained Men: A Placebo-Controlled, Double-Blind, Parallel-Group Comparison Study: Original Research. (2026). Journal of Exercise and Nutrition9(1). [JEN]

Imagine Pharma

IMG-1® is a proprietary 29-amino-acid bioactive polypeptide

Supplement designed to support healthy blood sugar metabolism, tissue repair, and progenitor cell activation

Progenalen® Pro Peptide

Hibiscus Collagen Alternative, from the calyx of H. sabdariffa.

VC-H1:

Hibiscus enzyme extract

 

VC-H1 supplementation significantly increased skin hydration, reduced the TEWL and keratin index, and improved deep moisture content. stimulate collagen growth.

Baek Y, Nguyen NH, Lee YI, Jung MJ, Kim IA, Lee SJ, Kim HM, Lee JH. Hibiscus Collagen Alternative (VC-H1) as an Oral Skin Rejuvenating Agent: A 12-Week Pilot Study. Int J Mol Sci. 2025 Jul 28;26(15):7291. [PMC]

Collagen

Morikol marine collagen tripeptides:  Gly‑X‑Y and Gly‑Pro‑Hyp (GPH)

Support skin and joint health.

Products – Morikol | DolCas Biotech

Mitochondrial-derived

MOTS-c:

MRWQEMGYIFYPRKLR

 

Significantly reduce the level of pro-inflammatory factors in mice and increase anti-inflammatory factors and insulin-stimulated glucose treatment rates, as well as glucose homeostasis.

Zheng Y, Wei Z, Wang T. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Front Endocrinol (Lausanne). 2023 Jan 25;14:1120533.  [PMC]

 

Synthetic

Biotinyl tripeptide 1: Biotinyl GHK

 

Stimulates hair follicle cells, thereby increasing their proliferation and activity. This promotes the growth of healthier, stronger hair strands and improves the overall health of the hair follicle.

Tosto R, Vecchio G, Bellia F. New Biotinylated GHK and Related Copper(II) Complex: Antioxidant and Antiglycant Properties In Vitro against Neurodegenerative Disorders. Molecules. 2023 Sep 20;28(18):6724. [PMC]

 

Synthetic

Acetyl tetrapeptide 3: Ac-KGHK-amide

Skin conditioner used in the anti-aging and anti-wrinkle cosmetics. Acetyl tetrapeptide-3 is indicated to boost collagen synthesis involved in hair growth.

[Capixyl] N2-Acetyl-L-lysylglycyl-L-histidyl-L-lysinamide; SCHEMBL29429145

 

Synthetic

Palmitoyl tetrapeptide 20 Pal-PEKK

Promotes hair pigmentation and reduce the hair greying process, an agonist of α-melanocyte-stimulating hormone (α-MSH).

Chavan D. Reversal of Premature Hair Graying Treated with a Topical Formulation Containing α-Melanocyte-Stimulating Hormone Agonist (Greyverse Solution 2%). Int J Trichology. 2022 Nov-Dec;14(6):207-209. [PMC]

 

Synthetic

Acetyl hexapeptide 1

Ac-(Nle)AH(DPhe)RW-amide, Melitane

 

Used in cosmetics and personal care products for its hydrating, brightening, and anti-aging properties. It draws moisture. By regulating melanin synthesis, it reduces hyperpigmentation and dark spots to leave a more even skin tone

 

[Pubchem]

 

Synthetic

Trifluoroacetyl Tripeptide-2 TFA-VYV

Anti aging: Inhibits progerin synthesis, a cell-aging accelerator protein.

 

[trifluoroacetyl-tripeptide-2]

 

Synthetic

Manganese Tripeptide-1

GHK-Mn+2

Reduces hyper-pigmentation and has antioxidant properties.

 

Pintea A, Manea A, Pintea C, Vlad RA, Bîrsan M, Antonoaea P, Rédai EM, Ciurba A. Peptides: Emerging Candidates for the Prevention and Treatment of Skin Senescence: A Review. Biomolecules. 2025 Jan 9;15(1):88. [PMC]

 

Porcine liver

APAAIGPYSQAVLVDR,  GLNQALVDLHALGSAR

Antioxidant properties

López-Pedrouso M, Borrajo P, Pateiro M, Lorenzo JM, Franco D. Antioxidant activity and peptidomic analysis of porcine liver hydrolysates using alcalase, bromelain, flavourzyme and papain enzymes. Food Res Int. 2020 Nov;137:109389. [PubMed]

 

Ferritin

GLNQALVDLHALGSAR, ALFQDVQKPSQDEWGK, LSGPQAGLGEYLFER

Antioxidant peptides

Trypsinogen

LGEHNIDVLEGNEQFINAAK

Antioxidant peptides

Soy protein

LQSGDALRVPSGTTYY, LNSGDALRVPSGTTYY

antioxidants

Durand E, Beaubier S, Ilic I, Fine F, Kapel R, Villeneuve P. Production and antioxidant capacity of bioactive peptides from plant biomass to counteract lipid oxidation. Curr Res Food Sci. 2021 May 29;4:365-397. [PMC]

 

 

 

“Bio-Synthesis is a business-to-business contract manufacturing and research organization. We do not sell GLP therapeutics or therapeutic peptides directly to the public, dispense prescription medications, or provide medical treatment.

Please note: This article is intended for scientific and industry discussion only and should not be interpreted as medical advice. Patients should consult licensed healthcare professionals regarding GLP-based therapies.

Patients and medical doctors please contact Lilly for more information”

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