Abbreviation
|
Description
|
|
|
ACE
|
Angiotensin-converting enzyme.
|
ACE2
|
Angiotensin-converting enzyme 2.
|
APN
|
Aminopeptidase.
|
ATP1A1
|
ATPase, Na+/K+ transporting, alpha 1 polypeptide.
|
COPB2
|
Coatomer protein complex, subunit beta 2 (beta prime).
|
CoVs
|
Coronaviruses.
|
CTD
|
C-terminal domain.
|
DDX1
|
ATP-dependent RNA helicase.
|
DPP4
|
Dipeptidyl-peptidase 4.
|
E
|
Envelope protein. Approximately 8-12 kDa in size, found in small quantities within the virion.
|
ER
|
Endoplasmic reticulum.
|
ERGIC
|
Endoplasmic reticulum Golgi intermediate compartment.
|
ExoN
|
Exoribonuclease.
|
GAPDH
|
Glyceraldehyde 3-phosphate dehydrogenase.
|
HE
|
Hemagglutinin-esterase.
|
HnRNP A1
|
Hetrogeneous nuclear ribonucleoprotein A1.
|
IFITM
|
Interferon inducing transmembrane protein.
|
M
|
Membrane protein. Most abundant structural protein in the virion. A small ~25-30 kDa protein with 3 transmembrane domains giving the virion its shape. Has a small N-terminal glycosylated ectodomain and a larger C-terminal endodomain extending 6-8 mm into the viral particle. Mediates attachment to the host receptor(s).
|
MADP1
|
Zinc Finger CCHC-type and RNA binding motif 1.
|
MERS-CoV
|
Middle Eastern Respiratory Syndrome Coronavirus.
|
MHV
|
Murine hepatitis virus.
|
Mpro
|
Main protease, a serine type protease, encoded by nsp5. Eleven cleavage events.
|
N
|
Nucleocapsid hosphor-protein. Present in the nucleocapsid. Maybe exist as a disulfide linked multimer. Has two separate domains, NYD and CTD. Both bind RNA. Binds viral genome in a beads-on-a-string type conformation. Binds TRS and the genomic packaging signal.
|
Nsps or NPS
|
Non-structural proteins.
|
NTD
|
N-terminal domain.
|
PABP
|
Poly A binding protein.
|
PCBP1/2
|
Poly(rC)-binding protein 1.
|
Ps
|
Packaging signal. A 69-nt stem – loop structure positioned in the 3’-end of ORF1b.
|
PLpro
|
Papain-like protease, encoded within nsp3. PLpro cleaves the nsp1/2, and nsp3/4 boundaries.
|
RBD
|
Receptor Binding Domain.
|
RdRp
|
RNA-dependent RNA polymerase.
|
RTC
|
Replicase-transcriptase complex.
|
S
|
Spike protein. Structural protein. A trimeric glycoprotein. Approximately, 150 kDa in size. Utilizes an N-terminal signal sequence to enter the endoplasmic reticulum (ER), heavily N-linked glycosylated. Homotrimers of the S protein make up the spike structure on the surface of the virus.
|
SARS-CoV
|
Severe Acute Respiratory Syndrome Coronavirus.
|
sgRNA
|
Sub-genomic mRNA.
|
TRS
|
Transcriptional regulatory sequence.
|
UTR
|
Untranslated region.
|