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Abbreviation
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Description
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ACE
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Angiotensin-converting enzyme.
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ACE2
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Angiotensin-converting enzyme 2.
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APN
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Aminopeptidase.
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ATP1A1
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ATPase, Na+/K+ transporting, alpha 1 polypeptide.
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COPB2
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Coatomer protein complex, subunit beta 2 (beta prime).
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CoVs
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Coronaviruses.
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CTD
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C-terminal domain.
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DDX1
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ATP-dependent RNA helicase.
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DPP4
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Dipeptidyl-peptidase 4.
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E
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Envelope protein. Approximately 8-12 kDa in size, found in small quantities within the virion.
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ER
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Endoplasmic reticulum.
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ERGIC
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Endoplasmic reticulum Golgi intermediate compartment.
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ExoN
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Exoribonuclease.
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GAPDH
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Glyceraldehyde 3-phosphate dehydrogenase.
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HE
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Hemagglutinin-esterase.
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HnRNP A1
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Hetrogeneous nuclear ribonucleoprotein A1.
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IFITM
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Interferon inducing transmembrane protein.
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M
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Membrane protein. Most abundant structural protein in the virion. A small ~25-30 kDa protein with 3 transmembrane domains giving the virion its shape. Has a small N-terminal glycosylated ectodomain and a larger C-terminal endodomain extending 6-8 mm into the viral particle. Mediates attachment to the host receptor(s).
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MADP1
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Zinc Finger CCHC-type and RNA binding motif 1.
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MERS-CoV
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Middle Eastern Respiratory Syndrome Coronavirus.
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MHV
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Murine hepatitis virus.
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Mpro
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Main protease, a serine type protease, encoded by nsp5. Eleven cleavage events.
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N
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Nucleocapsid hosphor-protein. Present in the nucleocapsid. Maybe exist as a disulfide linked multimer. Has two separate domains, NYD and CTD. Both bind RNA. Binds viral genome in a beads-on-a-string type conformation. Binds TRS and the genomic packaging signal.
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Nsps or NPS
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Non-structural proteins.
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NTD
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N-terminal domain.
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PABP
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Poly A binding protein.
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PCBP1/2
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Poly(rC)-binding protein 1.
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Ps
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Packaging signal. A 69-nt stem – loop structure positioned in the 3’-end of ORF1b.
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PLpro
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Papain-like protease, encoded within nsp3. PLpro cleaves the nsp1/2, and nsp3/4 boundaries.
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RBD
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Receptor Binding Domain.
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RdRp
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RNA-dependent RNA polymerase.
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RTC
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Replicase-transcriptase complex.
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S
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Spike protein. Structural protein. A trimeric glycoprotein. Approximately, 150 kDa in size. Utilizes an N-terminal signal sequence to enter the endoplasmic reticulum (ER), heavily N-linked glycosylated. Homotrimers of the S protein make up the spike structure on the surface of the virus.
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SARS-CoV
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Severe Acute Respiratory Syndrome Coronavirus.
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sgRNA
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Sub-genomic mRNA.
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TRS
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Transcriptional regulatory sequence.
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UTR
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Untranslated region.
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