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Abbreviations commonly used in corona virus research

 

Abbreviation

 Description

 

 

ACE

 Angiotensin-converting enzyme.

ACE2

 Angiotensin-converting enzyme 2.

APN

 Aminopeptidase.

ATP1A1

 ATPase, Na+/K+ transporting, alpha 1 polypeptide.

COPB2

 Coatomer protein complex, subunit beta 2 (beta prime).

CoVs

 Coronaviruses.

CTD

 C-terminal domain.

DDX1

 ATP-dependent RNA helicase.

DPP4

 Dipeptidyl-peptidase 4.

E

 Envelope protein. Approximately 8-12 kDa in size, found in small quantities within the virion. 

ER

 Endoplasmic reticulum.

ERGIC

 Endoplasmic reticulum Golgi intermediate compartment.

ExoN

 Exoribonuclease.

GAPDH

 Glyceraldehyde 3-phosphate dehydrogenase.

HE

 Hemagglutinin-esterase.

HnRNP A1

 Hetrogeneous nuclear ribonucleoprotein A1.

IFITM

 Interferon inducing transmembrane protein.

M

 Membrane protein. Most abundant structural protein in the virion. A small ~25-30 kDa protein with 3 transmembrane   domains giving the virion its shape. Has a small N-terminal glycosylated ectodomain and a larger C-terminal endodomain extending 6-8 mm into the viral particle. Mediates attachment to the host receptor(s).

MADP1

 Zinc Finger CCHC-type and RNA binding motif 1.

MERS-CoV

 Middle Eastern Respiratory Syndrome Coronavirus.

MHV

 Murine hepatitis virus.

Mpro

 Main protease, a serine type protease, encoded by nsp5. Eleven cleavage events.

N

 Nucleocapsid hosphor-protein. Present in the nucleocapsid. Maybe exist as a disulfide linked multimer. Has two separate domains, NYD and CTD. Both bind RNA. Binds viral genome in a beads-on-a-string type conformation. Binds TRS and the genomic packaging signal.

Nsps or NPS

 Non-structural proteins.

NTD

 N-terminal domain.

PABP

 Poly A binding protein.

PCBP1/2

 Poly(rC)-binding protein 1.

Ps

 Packaging signal. A 69-nt stem – loop structure positioned in the 3’-end of ORF1b.

PLpro

 Papain-like protease, encoded within nsp3. PLpro cleaves the nsp1/2, and nsp3/4 boundaries.

RBD

 Receptor Binding Domain.

RdRp

 RNA-dependent RNA polymerase.

RTC

 Replicase-transcriptase complex.

S

 Spike protein. Structural protein. A trimeric glycoprotein. Approximately, 150 kDa in size. Utilizes an N-terminal signal sequence to enter the endoplasmic reticulum (ER), heavily N-linked glycosylated. Homotrimers of the S protein make up the spike structure on the surface of the virus.

SARS-CoV

 Severe Acute Respiratory Syndrome Coronavirus.

sgRNA

 Sub-genomic mRNA.

TRS

 Transcriptional regulatory sequence.

UTR

 Untranslated region.

 

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