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Human Immunoglobulin Components

 
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11/01/2011

Human Immunoglobulin Components

Human Immunoglobulin Components
Property F(ab′)2 Fab′ Fc Secretory component J chain
H chain class / subclass (heavy chain) N/A1 N/A1 y1,2,3,4 IgA only IgA, IgM only
H chain MW 25 kDa 25 kDa 25 kDa N/A2 N/A2
L chain MW4 (light chain, K & λ) 23 kDa 23 kDa N/A3 N/A3 N/A3
Total MW 100 kDa5 50 kDa 50 kDa6 70 kDa 15 kDa
Ext. Coeff. 0.1%@280nm 1.5 1.5 1.2 Not available Not available
1.
Class determinants are not present on these fragments.
 
2.
Heavy chains are not present on these fragments.
 
3.
Light chains are not present on these fragments.
 
4.
Light chains are present on all immunoglobulins. In humans, K chains are found 67% of the time, and λ chains are found 33% of the time.
 
5.
2 heavy chain Fab fragments (25 kDa each) plus 2 light chains (25 kDa each).
 
6.
2 heavy chain Fc fragments (25 kDa each).