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Retro-Inverso Peptide

Retro-Inverso Peptides vs Full D-Peptides

Full D-Peptides (Mirror-Image Peptides)

Full D-peptides consist entirely of D-amino acids and are frequently used when maximum protease resistance is required.

  • High proteolytic stability
  • May alter receptor geometry
  • Often used in harsh biological environments

Retro-Inverso Peptides

Retro-inverso peptides reverse sequence direction and substitute D-residues to approximate side-chain topology of the parent peptide.

  • Potential stability improvement
  • Functional similarity is context-dependent
  • Requires experimental validation

Design Comparison Table

Strategy Protease Resistance Structural Fidelity
Single D-Substitution Moderate High
Full D-Peptide High Variable
Retro-Inverso Moderate–High Context-dependent

For synthesis support, see our D-amino acid peptide synthesis service .