Antisense Oligos

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Antisense Oligos

The use of antisense oligonucleotides (ASOs) was first identified, over twenty years ago, as a method to arrest gene expression levels both in vitro and in vivo where single-stranded DNA or RNA, in antisense configuration, can target a specific sense mRNA. The strategies in the design and chemistry of antisense compounds have become an effective tool in molecular biology basic research, genomics, proteomics, target screening/validation and drug discovery.

No set up fee

Deprotected, desalted, lyophilized

Purification by PAGE or RP-HPLC upon request

QC analysis by MALDI-TOF Mass spec, HPLC or PAGE

Fast delivery with high throughput capacity

Product Pricing

Base	100 nmol	250 nmol	1 umol	5 umol	10 umol
Chimeric DNA base	0.85/base	$1/base	$2/base	$10/base	$18./base
Phosphorothioate Bond	$5.00/bond	$5.00/bond	$2/base	$30/bond	$30/bond
2'-OMe	$8.50/base	$13.50/base	$20/base	$85/base	$160/base
3rd Generation Bridged Nucleic Acids (BNA3)	$120/base	$120/base	$200/base	Inquire	Inquire
5-Methyl dC	$50	$60	$90	$90	$360
RNase HPLC	$195	$195	$260	$365	$360
Na+ salt exchange	$80	$80	$80	$225	$225

A minimum will applied for oligo <10 bases. Yields and base price may vary depending on type of antisense synthesis..

Unmodified RNA Purifications Yields

Purifications	100 nmol	250 nmol	1 umol	5 umol	10 umol
PAGE	1 ODs	2 ODs	15 ODs	50 ODs	100 ODs
Phosphorothioate Bond	1 ODs	5 ODs	20 ODs	100 ODs	200 ODs
2'-OMe	1 ODs	5 ODs	20 ODs	100 ODs	200 ODs
Constrained Nucleotide	1 ODs	5 ODs	20 ODs	100 ODs	200 ODs
5-Methyl dC	1 ODs	2 ODs	10 ODs	50 ODs	100 ODs
RNase HPLC	0.5 OD	1 ODs	5 ODs	25 ODs	50 ODs

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Antisense Oligos