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Thiophosphate modified oligos are prepared at the time of synthesis by replacing an oxygen with a sulfur group at sugar-phosphate backbone. Thiophosphate modifications are often used in antisense drug development. Contact us for 5' and 3' Thiophosphate modified oligonucleotide synthesis.
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-20°C To -70°C Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.
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New reagent for the preparation of oligonucleotides involving a 5′-thiophosphate or a 5′-phosphate group
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