DBCO-Serinol Modified Oligo

Bio-Synthesis offers serveral oligonucleotide modifications for copper-free click reaction.  We offer several dibenzon-cyclooctyne (DBCO) modifiers, such as 5'-DBCL-TEG, a 15 atom triethylene glycol spacer, DBCO serinol may be inserted in between two bases at the phosphate backbone or DBCO-dT for inserting DBCO group at any position within the oligonucleotide. DBCO modified oligos can be used for conjugation with other biomolecules containing an azide functional group in DMSO, or aqueous buffers at room temperature. The reaction is robust with no side reactions which form  thermally and hydrolytically stable 1,2,3-triazole linkage.

Product Information

 

Product Name:

DBCO-Serinol Modified Oligo

Category:

click chemistry

Modification Code:

[DBCO Serinol]

Structure:

Purification:

HPLC or PAGE

Delivery Format:

Lyophilized

Shipping Conditions:

Room Temperature

Storage Conditions:

-20°C To -70°C
Oligonucleotides are stable in solution at 4°C for up to 2 weeks. Properly reconstituted material stored at -20°C should be stable for at least 6 months. Dried DNA (when kept at -20°C) in a nuclease-free environment should be stable for years.

Related Products:

>Cross-Link Base Modified Oligos

DBCO-TEG Cyclooctyne Oligonucleotide Modification

DBCO Copper-Free Oligo Modification

DBCO-dT Oligo Modification

DBCO NHS Oligo Modification

DBCO PEG1 NHS Oligo Modification

DBCO PEG4 NHS Oligo Modification

DBCO PEG5 NHS Oligo Modification

DBCO PEG8 NHS Oligo Modification

References/Citations:

1. Rostovtsev, V.V., et al., A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Angew Chem Int Ed Engl, 2002. 41(14): p. 2596-9.
2. Moses, J.E. and A.D. Moorhouse, The growing applications of click chemistry. Chem Soc Rev, 2007. 36(8): p. 1249-62.

 Modified oligo use for  Click Chemistry are sold by Bio-Synthesis for the end-user's internal research purpose only. See www.baseclick.org for further details.

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