Enhanced Diagnostic Tools
BNA (Bridged Nucleic Acids) are novel nucleic acid analogs designed on the basis of conformational behavior of natural nucleic acids. These nucleic acid analogs can be easily incorporated into natural oligonucleotide strands and allow the flexibility to design BNA/DNA, BNA/RNA hybrid oligo to accommodate the needs for extremely high and sequence-specific hybridization ability with natural nucleic acids, along with strong nuclease-resistant properties. To date, about 10 types of BNA have been developed. Individual types of BNA differ from each other in terms of binding affinity (hybridizing capability), nuclease resistance, etc.
Natural nucleic acids (DNA and RNA) have a higher degree of freedom in the chemical structure (degree of freedom in conformation). This feature is thermodynamically unfavorable for DNA-DNA, RNA-RNA double strand formation (hybridization). Improving the binding affinity (hybridizing capability) is an open issue related to the creation of synthetic nucleic acids.
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