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Perspectives on Chemistry and Therapeutic Applications of Locked Nucleic Acid (LNA)

This review focuses on the potentials and perspectives of Locked Nucleic Acid (LNA)-based oligonucleotides as therapeutic candidates. It briefly outlines various oligonucleotide- based gene silencing approaches with attention to the practical constraints leading to their downfall, as well as the diverse classes of modified nucleotide analogues that have been widely used until now to modulate gene expression. Their mode of action, characterstics, and inherent drawbacks are also stated.