GOR Method for Predicting Protein Secondary Structure from Amino Acid Sequence
JEAN GARNIER, JEAN-FRANqOIS GIBRAT, and BARRY ROBSON
10/19/2014
METHODS IN ENZYMOLOGY
How to extract properties from the amino acid sequence of a protein for understanding its function is one of the most timely and competitive areas of the biological sciences. It is related to a fundamental aspect of biology. A linear and ordered sequence of amino acids, coded and conserved by a linear and ordered sequence of nucleotide bases, codes for all that is characteristic of living organisms: specific and organized interactions in space and time between proteins, lipids, nucleic acids, and the cell metabolites. These characteristics depend on how a protein can fold in a unique active three-dimensional structure. This process is spontaneous under given environmental conditions, even though the living cell can add efficiency and control by use of some protein complexes, called chaperones, to catalyze this process.